Search on: WNT PROTEINS 
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Descriptor English:   Wnt Proteins 
Descriptor Spanish:   Proteínas Wnt 
Descriptor Portuguese:   Proteínas Wnt 
Synonyms English:   Wingless Type Proteins
Wnt Factors  
Tree Number:   D12.776.467.984
D23.529.984
Definition English:   Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN. 
History Note English:   2006(1987) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50759 
Unique Identifier:   D051153 

Occurrence in VHL: 		 

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